The TIGER Usability and Clinical Application Design Collaborative Team analyzed how to further define key concepts, patterns and trends and recommendations to health information technology (HIT) vendors and practitioners to assure useable clinical systems at the point of care. This report describes the background, methodology, findings, and recommendations for future work in this area. The focus on usability can lead to improvement of clinical IT products in three key areas: efficiency, effectiveness, and satisfaction. This means that appropriate design of IT can lead to more productivity, reduce errors, fit within workflow, improve accuracy, be easy to learn, and lead to more satisfied healthcare providers. TIGER recommends that nurses use the techniques described within this report in both purchasing decisions and to actively participate in IT product development efforts.